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| 1. | EXECUTIVE SUMMARY |
| 1.1. | Circuit construction for measuring biopotential |
| 1.2. | Neural Interface Processes |
| 1.3. | Viled and renewed neural interface patents |
| 1.4. | Top 20 assignees for neural interface patents |
| 1.5. | Geographic distribution of "neural interface" patents |
| 1.6. | Geographical distribution of "neural interface" patents |
| 1.7. | Trends in data acquisition |
| 1.8. | Data acquisition system trending examples |
| 1.9. | Trends in invasive neural interfaces |
| 1.10. | Invasive neural interface trending examples |
| 1.11. | Trends in non-invasive interfaces |
| 1.12. | Non-invasive neural interface trending examples |
| 1.13. | Overall forecast for neural interfaces |
| 2. | INTRODUCTION TO NEURAL INTERFACES |
| 2.1. | NIH BRAIN Initiative |
| 2.2. | How neurons normally function - axons and action potntials |
| 2.3. | How neurons normally function - the synaptic cleft |
| 2.4. | Meauring bioptntial |
| 2.5. | Circuit construction for measuring biopnential |
| 2.6. | An electrophysiology recording system |
| 2.7. | Electrodes: Introduction |
| 2.8. | Signals acquired in electrophysiology |
| 2.9. | EEG waveforms |
| 2.10. | ECoG waveforms |
| 2.11. | LFP waveforms |
| 2.12. | Neural Interface Processes |
| 2.13. | Pros and Cons of Non-invasive Interfaces |
| 2.14. | Pros and Cons of Invasive Interfaces |
| 2.15. | Pros and Cons of Select Implanted Probe Materials |
| 2.16. | Invasive and Non-invasive Neural Interfaces |
| 2.17. | Funtional Near-infrared Spectroscopy (fNIRS) |
| 2.18. | fNIR Examples |
| 2.19. | Electrodes as consumables vs. consumer electronics |
| 2.20. | Trends in data acquisition |
| 2.21. | Trends in invasive neural interfaces |
| 2.22. | Trends in non-invasive interfaces |
| 2.23. | Companies & institutions included in this report |
| 2.24. | Major company acquisitions |
| 3. | MARKET FORECASTS |
| 3.1. | Historical sales for DAQ systems |
| 3.2. | Historical sales for in vitro/vivo research probes |
| 3.3. | Historical sales for clinical research probes |
| 3.4. | Forecast DAQ and probes sales |
| 3.5. | Forecast DAQ systems and probes revenue |
| 3.6. | Potential interruption of traditional DAQs |
| 3.7. | Invasive probes market - Epilepsy |
| 3.8. | Invasive probes market - ICVPs |
| 3.9. | Invasive probes market - Speech conveyors |
| 3.10. | Invasive probes market - quadriplegics |
| 3.11. | Invasive probes markets forecast |
| 3.12. | EEG probe market - Epilepsy |
| 3.13. | EEG probe market - Traumatic Brain Injury |
| 3.14. | EEG probe market - Sleep disorders |
| 3.15. | EEG probe market - Speech conveyors |
| 3.16. | EEG probe market forecast |
| 3.17. | Disruption or coexistence with fNIRS? |
| 3.18. | EEG probe market forecast with fNIT |
| 3.19. | EEG headset market segmentation |
| 3.20. | Forecast EEG headsets |
| 3.21. | App subscriptions for EEG headsets |
| 3.22. | Overall forecast for neural interfaces |
| 4. | OVERVIEW OF PATENT LANDSCAPE |
| 4.1. | Broad patent landscape for "Neural interfaces" |
| 4.1.1. | Filed and renewed neural interface patents |
| 4.1.2. | Top 20 assignees for neural interface patents |
| 4.1.3. | Geographic distribution of "neural interface" patents |
| 4.1.4. | Top "neural interface" IPC codes |
| 4.1.5. | Top neural interface patent IPC codes by year |
| 4.2. | Patent landscapes for "Brain machine interfaces" |
| 4.2.1. | Filed and renewed "brain machine interface" patents |
| 4.2.2. | Top 20 assignees for "brain machine interface" patents |
| 4.2.3. | Geographical distribution of "brain machine interface" patents |
| 4.2.4. | Geographical distribution of "brain machine interface" patents |
| 4.2.5. | Top "brain machine interface" IPC codes |
| 4.2.6. | Top "brain machine interface" patent IPC codes by year |
| 4.3. | Patent landscape for "Brain computer interfaces" |
| 4.3.1. | Filed and renewed "brain computer interface" patents |
| 4.3.2. | Top 20 assignees for "brain computer interface" patents |
| 4.3.3. | Geographic distribution of "brain computer interface" patents |
| 4.3.4. | Top "brain computer interface" IPC codes |
| 4.3.5. | Top "brain computer interface" patent IPC codes by year |
| 5. | COMPETITIVE LANDSCAPE FOR NEUROPHYSIOLOGY EQUIPMENT |
| 5.1. | Neural Probes |
| 5.1.1. | A brief history of neural probes |
| 5.1.2. | Examples of neural electrodes |
| 5.1.3. | How neural probes are typically made |
| 5.1.4. | Considerations for electrode material selection |
| 5.1.5. | Considerations for insulating materials |
| 5.1.6. | Pros and Cons of select implanted probe materials |
| 5.1.7. | Research interest in neural probes |
| 5.1.8. | Patent interest in neural probes |
| 5.1.9. | NIH BRAIN Initiative® |
| 5.2. | In vitro/vivo research probes and microdrives |
| 5.2.1. | The University of Utah Center for Neural Interfaces |
| 5.2.2. | Blackrock Microsystems Partnerships and advances |
| 5.2.3. | Blackrock Microsystems Electrodes and electrode concepts |
| 5.2.4. | Tucker-Davis Technologies Probes |
| 5.2.5. | Neuro Nexus Company & Collaboration |
| 5.2.6. | Neuro NexusTechnologies |
| 5.2.7. | Neuro Nexus Standard probes and vector arrays |
| 5.2.8. | Neuro Nexus dDrive and pDrive (Beta) |
| 5.2.9. | Graymatter ResearchMicrodrives |
| 5.2.10. | Thomas Recording Technologies |
| 5.2.11. | Thomas Recording Microelectrodes |
| 5.2.12. | Thomas Recording Microdrives |
| 5.2.13. | Thomas Recording Chronic recording devices |
| 5.2.14. | CorTec Electrode technology |
| 5.2.15. | CorTec Hermetic encapsulation technology |
| 5.2.16. | Cambridge NeuroTech Probes |
| 5.2.17. | Cambridge NeuroTech Probe advantages |
| 5.2.18. | WISE Technology |
| 5.2.19. | FHC Inc. Technology |
| 5.2.20. | FHC Inc. Research microelectrodes |
| 5.2.21. | Atlas Neuro Probe technology |
| 5.2.22. | Integer Neuromodulation solutions |
| 5.2.23. | MicroProbes for Life Science Technologies |
| 5.2.24. | MicroProbes for Life Science Single, bipolar, and macro electrodes |
| 5.2.25. | MicroProbes for Life Science Concentric microelectrodes |
| 5.2.26. | MicroProbes for Life Science Arrays |
| 5.2.27. | MicroProbes for Life Science and the future of Tungsten microelectrode arrays |
| 5.2.28. | Qwane Biosciences Microelectrode arrays |
| 5.2.29. | Multichannel systems Microelectrode arrays |
| 5.2.30. | HEKA Electrophysiology electrodes |
| 5.2.31. | 3Brain Microelectrode arrays |
| 5.2.32. | Plexon Electrodes |
| 5.2.33. | Novela advanced microsystems Electrode arrays |
| 5.2.34. | Alpha Omega Electrodes |
| 5.2.35. | Alpha Omega Clinical electrode and microdrive |
| 5.2.36. | Invivo1 Electrodes |
| 5.2.37. | Bio-Signal Technologies Electrode arrays |
| 5.2.38. | A-M Systems Electrodes |
| 5.2.39. | ADInstruments Neurophysiology equipment |
| 5.2.40. | ADInstruments Wireless implants for research |
| 5.2.41. | University of Texas |
| 5.2.42. | Implantable fNIRS probe |
| 5.3. | Clinical research probes |
| 5.3.1. | Special considerations for clinical probes & related devices |
| 5.3.2. | FHC Clinical microelectrodes |
| 5.3.3. | AD-Tech Technologies |
| 5.3.4. | AD-Tech Subdural electrodes |
| 5.3.5. | AD-Tech Depth electrodes |
| 5.3.6. | AD-Tech Intraoperative monitoring electrodes |
| 5.3.7. | PMT Corporation Electrodes |
| 5.3.8. | Digitimer Subdermal electrodes |
| 5.3.9. | Needle Electrodes |
| 5.4. | Connectors for probes |
| 5.4.1. | Available connector types |
| 5.4.2. | Omnetics Connectors for neuroscience |
| 5.4.3. | Samtec Connectors |
| 5.4.4. | Tucker-Davis Technologies ZIF-Clip® Connectors |
| 5.4.5. | Atlas Neuro Connector and EIB technology |
| 5.4.6. | CorTec Interconnection technology |
| 5.4.7. | Trends in invasive neural interfaces |
| 5.5. | Surface electrodes |
| 5.5.1. | Properties of wearable electrodes |
| 5.5.2. | Dry electrodes: Challenges and solutions |
| 5.5.3. | Approaches for improving electrode performance |
| 5.5.4. | Consumer EEG products and prototypes |
| 5.5.5. | How EEGs work |
| 5.5.6. | EGI Electrodes |
| 5.5.7. | Advanced Brain Monitoring EEG headsets for medical use |
| 5.5.8. | Advanced Brain Monitoring EEG headsets for research use |
| 5.5.9. | Advanced Brain Monitoring software |
| 5.5.10. | Brain Products & EASYCAP, Brain Vision Solutions |
| 5.5.11. | Compumedics Electrodes |
| 5.5.12. | Genuine Grass EEG electrodes |
| 5.5.13. | ADInstruments EEG surface electrodes |
| 5.5.14. | IDUN HealthTech Dry electrodes for health monitoring |
| 5.5.15. | A-M Systems Surface electrodes |
| 5.5.16. | NeuroSky EEG Biosensors and headset |
| 5.5.17. | Digitimer Surface electrodes |
| 5.5.18. | MindMedia EEG electrodes |
| 5.5.19. | Medtronic Electrodes for brain monitoring |
| 5.5.20. | IMEC and the Holst Centre |
| 5.5.21. | BIOPAC EEG & fNIR systems |
| 5.5.22. | Focus BCI Kits |
| 5.5.23. | Functional Near-Infrared Spectroscopy (fNIRS) |
| 5.5.24. | Rogue Resolutions & Brainsight NIRS fNIRS systems |
| 5.5.25. | NIRX fNIRS optrodes |
| 5.5.26. | NIRX Cap layouts |
| 5.5.27. | Gowerlabs fNIRS headgear |
| 5.5.28. | Artinis fNIRS and multimodal caps |
| 5.5.29. | Trends in non-invasive interfaces |
| 6. | DATA ACQUISITION (DAQ) SYSTEMS AND SOFTWARE |
| 6.1. | In vivo research and clinical DAQ systems and software |
| 6.1.1. | Tucker-Davis Technologies Preamplifiers |
| 6.1.2. | Tucker-Davis Technologies Processors |
| 6.1.3. | Tucker-Davis Technologies Software |
| 6.1.4. | Intan Amplifier chips |
| 6.1.5. | Cambridge NeuroTech Technologies |
| 6.1.6. | Blackrock Microsystems Headstages |
| 6.1.7. | Blackrock Microsystems Data acquisition systems |
| 6.1.8. | Triangle Biosystems Wireless DAQ systems |
| 6.1.9. | Triangle Biosystems Recording and analysis software |
| 6.1.10. | White Matter Headstages |
| 6.1.11. | Ripple Front ends (headstages/amplifiers) |
| 6.1.12. | HEKA Connectors, headstages, and amplifiers |
| 6.1.13. | Plexon Headstages |
| 6.1.14. | Plexon Preamplifier and additional accessories |
| 6.1.15. | Plexon Data acquisition systems & software |
| 6.1.16. | Thomas Recording Preamplifiers and amplifiers |
| 6.1.17. | Thomas Recording Data acquisition system and software |
| 6.1.18. | Digitimer |
| 6.1.19. | Clinical EEG/EMG amplifiers |
| 6.1.20. | Digitimer Neurolog system |
| 6.1.21. | Bio-Signal Technologies Headstages |
| 6.1.22. | Bio-Signal Technologies Wireless amplifier |
| 6.1.23. | Bio-Signal Technologies Data acquisition systems & software |
| 6.1.24. | Brain Vision SolutionsAmplifiers |
| 6.1.25. | Brain Products Software |
| 6.1.26. | Brain Products & Smarting |
| 6.1.27. | Compumedics Digitizers |
| 6.1.28. | Compumedics Amplifiers |
| 6.1.29. | Compumedics Recording systems and software |
| 6.1.30. | A-M Systems Intracellular amplifiers |
| 6.1.31. | A-M Systems Extracellular amplifiers |
| 6.1.32. | A-M Systems Connectors and headstages |
| 6.1.33. | CED Amplifier |
| 6.1.34. | CED Data acquisition system and software |
| 6.1.35. | ADInstruments Bio Amps |
| 6.1.36. | ADInstruments Data acquisition hardware and software |
| 6.1.37. | Natus distributed Grass and Xltek amplifiers |
| 6.1.38. | Natus Software |
| 6.1.39. | White Matter Data acquisition system |
| 6.1.40. | Ripple Processors |
| 6.1.41. | Ripple Laboratory research capabilities |
| 6.1.42. | Ripple Clinical capabilities |
| 6.1.43. | NeuraLynx Research technology |
| 6.1.44. | NeuraLynx Clinical technology |
| 6.1.45. | Alpha Omega Research data acquisition |
| 6.1.46. | Alpha Omega Clinical data acquisition |
| 6.1.47. | EGI Recording devices and software |
| 6.1.48. | DataWave Technologies Recording and analysis software |
| 6.1.49. | HEKA Data acquisition hardware & software |
| 6.1.50. | A.M.P.I. Stimulators for neuroscience research |
| 6.1.51. | Mind Media Data acquisition systems |
| 6.1.52. | Mind Media Software |
| 6.1.53. | JAGA Systems Wireless recording devices |
| 6.1.54. | JAGA Systems Software |
| 6.1.55. | Medtronic Systems for brain monitoring |
| 6.1.56. | Neuroexplorer Data analysis software for neurophysiology |
| 6.1.57. | LeafLabs and data acquisition systems for neuroscience |
| 6.2. | In vitro research DAQ systems and software |
| 6.2.1. | Multi Channel Systems Headstages |
| 6.2.2. | Multi Channel Systems Data acquisition systems & software |
| 6.2.3. | 3Brain Data acquisition system and software |
| 6.3. | fNIRS DAQ systems and software |
| 6.3.1. | Rogue Resolutions fNIRS imaging software |
| 6.3.2. | NIRX fNIRS data acquisition |
| 6.3.3. | Gowerlabs NTS Imaging systems |
| 6.3.4. | Artinis data acquisition |
| 6.3.5. | Trends in data acquisition |
| 7. | APPLICATIONS FOR INVASIVE NEURAL INTERFACES |
| 7.1. | ParadromicsTechnology |
| 7.2. | Synchron Technology |
| 7.3. | Inscopix Miniature microscope |
| 7.4. | NeuroLux Optogenetics system |
| 7.5. | Hanyang University and ECoG BMIs |
| 7.6. | BrainGate Technology |
| 7.7. | Andersen Lab at Caltech |
| 7.8. | Schwartz Motorlab at the University of Pittsburgh |
| 7.9. | CorTec Technology |
| 7.10. | University of Pittsburgh with DARPA |
| 7.11. | EPFL and BMI's for Rehabilitation |
| 7.12. | Mayo Clinic EES trial |
| 7.13. | Medtronic's Spinal Cord Stimulation technology |
| 7.14. | Sensars Technology |
| 7.15. | Sensars Pilot trial |
| 7.16. | Cambridge Bio-Augmentation Systems technology |
| 7.17. | Synergia Medical and Next Generation implants |
| 7.18. | The Brain Center Rudolf Magnus and their Utrecht Neuroprosthesis Technology |
| 7.19. | NeuroPace and seizure treatment |
| 7.20. | Kernel and memory implants |
| 7.21. | BCI's as Intracortical visual prosthetics |
| 7.22. | Second Sight Technologies |
| 7.23. | Monash Vision Group Technology |
| 7.24. | Monash Vision Group Gennaris Bionic Vision System |
| 7.25. | Illinois Institute of Technology Intracortical Visual Prosthesis (ICVP) |
| 8. | APPLICATIONS FOR NON-INVASIVE NEURAL INTERFACES |
| 8.1. | Samsung and BCI's for early stroke detection |
| 8.2. | ElMindA and BCIs for disease diagnosis and treatment |
| 8.3. | Avertus Inc. High-accuracy epilepsy monitoring |
| 8.4. | Global Neuro-Diagnostics Video EEG monitoring |
| 8.5. | Neurotech EEG Monitoring |
| 8.6. | Advanced Brain Monitoring EEG monitoring |
| 8.7. | Neurovigil and BCIs for sleep monitoring and diagnosis |
| 8.8. | The University of Utah & Blackrock Microsystems |
| 8.9. | Neurolutions and BCIs as therapies |
| 8.10. | BrainRobotics and EMG-based prosthetic limbs |
| 8.11. | Halo Neuroscience and BCIs for training |
| 8.12. | NIRX BCI's for LIS |
| 8.13. | mindBEAGLE and BCI's for LIS |
| 8.14. | Conscious Labs and EEG headphones |
| 8.15. | NeuroSky and EEG earbuds |
| 8.16. | NeuroSky and "mind-controlled" toys |
| 8.17. | Mindmaze BCIs |
| 8.18. | Neurable and BCI's for AR/VR manipulation |
| 8.19. | 4DForce and BCIs for gaming |
| 8.20. | SmartCap and fatigue monitoring |
| 8.21. | Freer Logic LLC and distraction monitoring |
| 8.22. | Northrop Grumman and mind-reading binoculars |
| 8.23. | Neuromatters and BCIs for intelligence gathering |
| 8.24. | Neuromatters and BCIs for content testing |
| 8.25. | Advanced Brain Monitoring and BCIs for market and usability research |
| 8.26. | BrainCoand versatile BCIs for home and school |
| 8.27. | Emotiv and affordable EEG sets |
| 8.28. | Emotiv and affordable EEG sets |
| 8.29. | Muse by Interaxon |
| 8.30. | NeuroPro headsets and software |
| 8.31. | OpenBCI & Open source BCIs |
| 8.32. | Trends in non-invasive interfaces |
| 9. | NEUROPHYSIOLOGY SUPPLIES & EQUIPMENT DISTRIBUTORS |
| 9.1. | Bionic |
| 9.2. | ALA Scientific Instruments |
| 9.3. | KF Technology and MedCat Supplies |
| 9.4. | Natus EEG electrodes |
| 9.5. | Kee Change Technology |
| 9.6. | Consolidate Neuro Supply and Bioengenesis |
| 9.7. | Acknowledgements |
| Slides | 338 |
|---|---|
| Forecasts to | 2028 |