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1. | EXECUTIVE SUMMARY |
1.1. | Executive introduction: Electronic skin patches |
1.2. | Application overview |
1.3. | Applications, market sizes and outlook |
1.4. | The diabetes management ecosystem |
1.5. | CGM leads the way |
1.6. | Insulin pumps and patch pumps |
1.7. | The outlook for diabetes management |
1.8. | Monitoring the heart via skin patches |
1.9. | Players and product types in cardiac monitoring |
1.10. | Cardiac monitoring skin patches: Historic data: 2010-2020 |
1.11. | Cardiac monitoring skin patches: Market forecasts |
1.12. | Application potential for general purpose devices |
1.13. | Historic market data, 2010-2020 |
1.14. | Market forecasts, 2021-2031 |
1.15. | Skin patch temperature sensing: Use cases across 13 case studies |
1.16. | Key conclusions: Temperature sensing skin patches |
1.17. | Electrical stimulation product types |
1.18. | Skin patches in bioelectronic medicine |
1.19. | Electrical stimulation via skin patches: Market data (2010-2019) |
1.20. | Electrical stimulation via skin patches: Market forecast (2021-2031) |
1.21. | Iontophoresis via skin patches: Market data (2010-2019) |
1.22. | Iontophoresis via skin patches: Market forecast (2020-2030) |
1.23. | Key conclusions: Iontophoresis |
1.24. | Examples of players from case studies |
2. | INTRODUCTION |
2.1.1. | The case for skin patches: Augmenting the human body |
2.1.2. | The case for skin patches: Improving device form factor |
2.1.3. | Definitions and exclusions |
2.1.4. | History of skin patches |
2.1.5. | Applications, market sizes and outlook |
2.1.6. | Reimbursement drives commercial business models |
2.1.7. | Patents: Total active patents by assignee |
2.1.8. | Patents over time |
2.1.9. | Patents: Active and strong patents by assignee |
2.1.10. | Context: Wearables hype |
2.1.11. | Glossary |
2.1.12. | Glossary (continued) |
2.2. | Application overview |
2.2.1. | Skin patches competing with established products |
2.2.2. | New market creation around skin patches |
2.2.3. | Section contents |
3. | DIABETES MANAGEMENT VIA SKIN PATCHES |
3.1.1. | Background: Introduction to diabetes |
3.1.2. | The prevalence of diabetes |
3.1.3. | Background: Diabetes on the rise |
3.1.4. | Background: The cost of diabetes |
3.1.5. | Background: The diabetes management process |
3.1.6. | Diabetes management ecosystem |
3.1.7. | Diabetes management device roadmap: Summary |
3.1.8. | Diabetes management device roadmap: Sensors |
3.1.9. | Coverage in this report |
3.2. | Continuous glucose monitoring (CGM) |
3.2.1. | The case for continuous glucose monitoring (CGM) |
3.2.2. | Anatomy of a typical CGM device |
3.2.3. | CGM is deployed via skin patches |
3.2.4. | Comparison metrics for CGM devices |
3.2.5. | Example: Accuracy of CGM devices over time |
3.2.6. | CGM: Technology |
3.2.7. | CGM sensor chemistry |
3.2.8. | Sensor filament structure |
3.3. | CGM: Overview of key players |
3.3.1. | CGM: Overview of key players |
3.3.2. | Abbott Laboratories: Introduction |
3.3.3. | Abbott Laboratories: CGM business |
3.3.4. | Abbott: Freestyle® Libre |
3.3.5. | Abbott: "Wired enzyme" |
3.3.6. | Abbott: Device and sensor structure |
3.3.7. | Dexcom: Introduction |
3.3.8. | Dexcom: CGM products |
3.3.9. | Dexcom: Sensor structure |
3.3.10. | Medtronic: Introduction |
3.3.11. | Medtronic: Diabetes & CGM business |
3.3.12. | Medtronic: Sensor structure |
3.3.13. | Medtronic: Towards closed loop |
3.3.14. | Medtronic: Patents in CGM |
3.3.15. | Roche: Overview |
3.3.16. | Roche: Patents in CGM |
3.3.17. | Senseonics |
3.3.18. | Ascensia & POCTech |
3.3.19. | Medtrum |
3.3.20. | Medtrum: CGM devices & insulin pumps |
3.3.21. | Medtrum: Sensing technology |
3.3.22. | Medtrum: Specific development steps towards the artificial pancreas |
3.3.23. | Medtrum |
3.3.24. | AgaMatrix & WaveForm Technologies |
3.3.25. | Infinovo |
3.3.26. | PKVitality |
3.3.27. | Sano |
3.3.28. | Verily / Google: Contact lenses |
3.4. | Non-invasive glucose monitoring |
3.4.1. | Background: Glucose in the body |
3.4.2. | Assessment of different analytes for glucose monitoring |
3.4.3. | Key criteria for assessing accuracy |
3.4.4. | In Context: FDA requirements |
3.4.5. | Approaches for non-invasive glucose monitoring |
3.4.6. | Companies Using Each Technique |
3.4.7. | Companies Using Each Technique (Other Fluids) |
3.4.8. | When will non-invasive glucose monitoring be commercialised? |
3.4.9. | Notable Quotes on Non-Invasive Glucose Monitoring |
3.5. | Insulin delivery |
3.5.1. | Insulin delivery: Introduction |
3.5.2. | Diabetes management device roadmap: Insulin delivery |
3.5.3. | Insulin pumps: Introduction |
3.5.4. | Insulin pumps currently available |
3.5.5. | Insulin pump breakdown |
3.5.6. | Insulin patch pumps |
3.5.7. | Example: Patch pumps at Medtronic? |
3.5.8. | Pricing models for patch pumps vs traditional options |
3.5.9. | Insulin pump market |
3.5.10. | Insulin pump players and market share |
3.5.11. | Markets: Patch pumps vs traditional infusion pumps |
3.5.12. | Comparing insulin pumps and CGM |
3.5.13. | Outlook for insulin pumps |
3.6. | Linking insulin pumps and CGM: Towards closed loop and the artificial pancreas |
3.6.1. | Today: Hybrid closed loop systems |
3.6.2. | Example: Progress from Medtronic |
3.6.3. | The objective: Closing the feedback loop |
3.6.4. | Examples and partnerships |
3.6.5. | Example: DiabeLoop |
3.6.6. | Medtrum: Efforts towards the artificial pancreas |
3.7. | Market data: Historic & forecasts |
3.7.1. | Skin patches and diabetes: Forecast summary |
3.7.2. | Overview: CGM market share and players in 2020 |
3.7.3. | A shifting focus in diabetes management, Historic data: 2010-2020 |
3.7.4. | Test strip business in decline |
3.7.5. | The growth of CGM accelerates |
3.7.6. | The insulin pump market |
3.7.7. | Markets: Patch pumps vs traditional infusion pumps |
3.7.8. | Quantitative forecasts for diabetes and CGM |
3.7.9. | Building a top-down forecast scenario |
3.7.10. | CGM: Market forecast (revenue) |
3.7.11. | CGM: Market forecast (sales volumes) |
3.7.12. | Insulin pumps: Market forecast (revenue) |
3.7.13. | Insulin pumps: Market forecast (sales volumes) |
3.7.14. | Full datasets: Skin patches in diabetes management, 2010-2020 (historic) & 2021-2031 (forecast) |
3.7.15. | Full datasets: Diabetes management markets, 2010-2020 (historic) & 2021-2031 (forecast) |
4. | GENERAL PATIENT MONITORING: VITAL SIGNS AND RELATED METRICS |
4.1. | Introduction |
4.1.1. | Introduction |
4.1.2. | Drivers and requirements for skin patches |
4.1.3. | Application potential for general purpose devices |
4.1.4. | Deployment challenges for general monitoring devices |
4.1.5. | Evolving market dynamics over time |
4.1.6. | General monitoring needs an infrastructure that only the larger players can provide |
4.1.7. | Historic market data, 2010-2020 |
4.1.8. | Market forecasts, 2021-2031 |
4.2. | Inpatient monitoring |
4.2.1. | Traditional inpatient monitoring |
4.2.2. | The case for removing the wires |
4.2.3. | Emerging skin patch options |
4.2.4. | Players and approaches |
4.2.5. | Philips |
4.2.6. | BioIntelliSense |
4.2.7. | VivaLNK |
4.2.8. | The Surgical Company (formerly Sensium) |
4.2.9. | VitalConnect |
4.2.10. | Isansys Lifecare |
4.2.11. | Market data and forecasts for wireless inpatient monitoring |
4.3. | Outpatient monitoring with skin patches |
4.3.1. | Introduction |
4.3.2. | LifeSignals |
4.3.3. | Samsung |
4.3.4. | MC10 |
4.3.5. | DevInnova / Scaleo Medical |
4.3.6. | Avanix |
4.3.7. | Avanix - business model and target milestones |
4.3.8. | Historic: Qualcomm Life |
4.3.9. | Qualcomm Life / Capsule Technologies |
4.3.10. | Market data and forecasts for wireless outpatient monitoring |
5. | CARDIOVASCULAR MONITORING SKIN PATCHES |
5.1.1. | Introduction - Cardiovascular monitoring via wearable devices |
5.1.2. | Introduction - Measuring biopotential |
5.1.3. | Technology overview - the circuitry for measuring biopotential |
5.1.4. | Introduction - Electrocardiography (ECG, or EKG) |
5.1.5. | Devices for cardiac monitoring |
5.1.6. | Cardiac monitoring device types - skin patches |
5.1.7. | Companies and product types |
5.1.8. | Technology overview - electrode properties |
5.1.9. | Disposable Ag/AgCl electrodes |
5.1.10. | Electrodes: Traditional approaches |
5.1.11. | Skin patches with disposable electrodes |
5.1.12. | Skin patches with integrated electrodes |
5.2. | Reimbursement |
5.2.1. | Reimbursement codes for wearable cardiac monitors |
5.2.2. | 2021: New reimbursement structure in place |
5.2.3. | Fallout and outlook following the 2021 code change |
5.3. | Players |
5.3.1. | Summaries and interviews with 20 industry players |
5.3.2. | Philips |
5.3.3. | BioTelemetry, Inc. |
5.3.4. | BioTelemetry: Timeline |
5.3.5. | iRhythm |
5.3.6. | ScottCare |
5.3.7. | Fukuda Denshi |
5.3.8. | Fujita Medical Instruments |
5.3.9. | Bittium |
5.3.10. | Byteflies & Quad Industries |
5.3.11. | Cardiomo |
5.3.12. | Vivomi |
5.3.13. | QT Medical |
5.3.14. | SWMedical |
5.3.15. | SWMedical - CardiNova |
5.3.16. | Seers Technology |
5.3.17. | Rooti |
5.3.18. | Preventice Solutions |
5.3.19. | Sigknow |
5.3.20. | Borsam |
5.3.21. | Cortrium |
5.3.22. | Qardio |
5.3.23. | Qardio (2) |
5.3.24. | Holst Center: Skin patches |
5.3.25. | Tatch |
5.3.26. | Mezoo |
5.3.27. | S'UIMIN |
5.3.28. | Medtronic: SEEQ MCT (discontinued) |
5.3.29. | LumiraDx / FitLinxx: Ampstrip (discontinued) |
5.4. | Competition with other form factors |
5.4.1. | Other form factors for ambulatory cardiac monitoring |
5.4.2. | Wearable vs implantable monitoring |
5.4.3. | Example: Medtronic (SEEQ & LINQ) |
5.4.4. | Comparison: Chest straps |
5.4.5. | Comparison: Apparel |
5.4.6. | Comparison: Portable devices |
5.4.7. | Comparison: Smartwatch optical HRM |
5.5. | Market data and forecasts |
5.5.1. | Market overview and forecasts |
5.5.2. | The impact of COVID-19 |
5.5.3. | Cardiac monitoring skin patches: Historic data: 2010-2020 |
5.5.4. | Cardiac monitoring skin patches: Market forecasts |
5.5.5. | Full dataset with table: 2010-2019 (historic) & 2020-2030 (forecast) |
5.5.6. | Key conclusions: cardiac monitoring skin patches |
6. | FOETAL HEART RATE MONITORING |
6.1. | Foetal monitoring |
6.2. | Monica Healthcare |
6.3. | GE Healthcare |
6.4. | Philips |
6.5. | Key conclusions and market data |
7. | TEMPERATURE SENSING SKIN PATCHES |
7.1. | Introduction - Body Temperature |
7.2. | Temperature sensing technology options |
7.3. | Approaches and standards for medical temperature sensing |
7.4. | Skin patches for temperature sensing |
7.5. | Skin patch temperature sensing: Use cases across 13 case studies |
7.6. | VivaLNK |
7.7. | VivaLNK & Reckitt Benckiser |
7.8. | VivaLNK: COVID-19 response |
7.9. | BioIntelliSense |
7.10. | Blue Spark |
7.11. | Blue Spark & TempTraq® |
7.12. | Life Science Technology |
7.13. | Isansys Lifecare |
7.14. | Raiing Medical |
7.15. | Bonbouton |
7.16. | CSEM |
7.17. | Covestro |
7.18. | Chois Technology |
7.19. | Alternative options: Tympanic temperature sensing |
7.20. | Key conclusions: Temperature sensing skin patches |
8. | ELECTRICAL STIMULATION WITH SKIN PATCHES |
8.1.1. | Introduction: Types of electrical stimulation |
8.1.2. | Differentiation for electrical stimulation |
8.1.3. | Nomenclature in electrical stimulation |
8.1.4. | Electrical stimulation product types |
8.1.5. | Medical vs non-medical devices |
8.1.6. | Bioelectronic Medicine: Definition and background |
8.1.7. | Major Forms of Bioelectronic Medicine |
8.1.8. | The Evolution of Bioelectronic Medicine |
8.1.9. | Skin patches in bioelectronic medicine |
8.2. | TENS |
8.2.1. | TENS - Introduction |
8.2.2. | Innovative Health Solutions: NSS-2 Bridge |
8.2.3. | BeWellConnect: MyTens |
8.2.4. | NeuroMetrix: Quell |
8.2.5. | Theranica: Nerivio Migra |
8.3. | EMS / NMES / FES |
8.3.1. | EMS, NMES and FES |
8.3.2. | Applications of EMS / NMES |
8.3.3. | Example: Russian Stimulation |
8.3.4. | Example: Therapeutic settings and uses |
8.3.5. | Properties of the stimulation (as presented with a therapeutic focus) |
8.3.6. | First Kind Medical: geko |
8.3.7. | Example: HiDow |
8.3.8. | Example: HiDow |
8.3.9. | Hivox Biotek |
8.4. | Market data and forecasts |
8.4.1. | Electrical stimulation via skin patches: Market data (2010-2019) |
8.4.2. | Electrical stimulation via skin patches: Market forecast (2021-2031) |
9. | IONTOPHORESIS SKIN PATCHES: COSMETICS AND DRUG DELIVERY |
9.1.1. | Introduction - Iontophoresis |
9.1.2. | Cosmetics |
9.1.3. | Cosmetic skin patches |
9.1.4. | Estée Lauder |
9.1.5. | BioBliss™, Iontera, Patchology |
9.1.6. | FeeliGreen (Feeligold) |
9.2. | Drug delivery |
9.2.1. | Iontophoresis for drug delivery |
9.2.2. | Drugs studied for iontophoretic delivery |
9.2.3. | Commercial activity with drug delivery patches |
9.2.4. | FeeliGreen (Feelicare) |
9.2.5. | Seoul National University: Parkinson's medication via skin patches |
9.3. | Reverse iontophoresis |
9.3.1. | Reverse Iontophoresis |
9.3.2. | Example: GlucoWatch |
9.3.3. | Nemaura Medical: sugarBEAT |
9.4. | Market forecasts and conclusions |
9.4.1. | Iontophoresis via skin patches: Market data (2010-2019) |
9.4.2. | Iontophoresis via skin patches: Market forecast (2020-2030) |
9.4.3. | Key conclusions: Iontophoresis |
10. | SWEAT SENSING: SWEAT RATE AND BIOMARKERS |
10.1.1. | Introduction - Sweat sensing |
10.2. | Measuring sweat rate |
10.2.1. | Technology overview - measuring bioimpedance |
10.2.2. | Technology overview - Galvanic skin response (GSR) |
10.2.3. | Technology overview - humidity sensors for sweat |
10.2.4. | GE Global Research |
10.3. | Sensing biomarkers in sweat |
10.3.1. | Technology overview - chemical sensing in sweat |
10.3.2. | Sweat vs other sources of analytes |
10.3.3. | Analytes in sweat |
10.3.4. | Diagnostics with chemical sensors |
10.3.5. | Monitoring blood cholesterol using biosensors |
10.3.6. | Towards wearable cholesterol monitoring |
10.3.7. | Example: sweat alcohol detection |
10.3.8. | Lactic acid monitoring for athletes |
10.3.9. | Traditional lactic acid monitors |
10.3.10. | Microneedles to analyse lactic acid in interstitial fluid |
10.3.11. | Increasingly portable diagnosis of bovine and human TB |
10.3.12. | Wearable diagnostic tests for cystic fibrosis |
10.3.13. | Technology overview: Chemical sensing |
10.3.14. | Biolinq |
10.3.15. | Kenzen |
10.3.16. | Milo Sensors |
10.3.17. | PARC / UCSD |
10.3.18. | Stanford and UC Berkeley |
10.3.19. | Xsensio |
10.3.20. | Epicore Biosystems |
10.3.21. | Eccrine Systems (closed) |
10.3.22. | Key conclusions: Sweat sensing |
11. | WOUND MONITORING AND TREATMENT WITH SKIN PATCHES |
11.1. | Wound Monitoring |
11.2. | Wound Monitoring: KAUST |
11.3. | Wound Monitoring: Purdue University |
11.4. | Wound Monitoring: Tufts University |
11.5. | Wound Monitoring: Tyndall National Institute |
11.6. | Wound Monitoring: UC Berkeley |
11.7. | Wound Monitoring: UCSD |
11.8. | Wound Monitoring: VTT |
11.9. | Wound Treatment |
12. | MOTION SENSING WITH SKIN PATCHES |
12.1.1. | Introduction - Monitoring motion via skin patches |
12.1.2. | Different modes for sensing motion |
12.2. | Measuring motion with inertial measurement units |
12.2.1. | Introduction - Inertial measurement units |
12.2.2. | Measuring motion with IMUs: Examples |
12.2.3. | Value chain and examples of players |
12.2.4. | IMUs in skin patches |
12.3. | Measuring motion with conformal sensors |
12.3.1. | Introduction - alternatives for measuring motion |
12.3.2. | Technology overview - Resistive/piezoresistive sensing |
12.3.3. | Players and industry dynamic |
12.3.4. | Peratech |
12.3.5. | Quantum tunnelling composite: QTC® |
12.3.6. | QTC® vs. FSR™ vs. piezoresistor? |
12.3.7. | Bebop Sensors |
12.3.8. | Bainisha |
12.3.9. | Technology overview - Capacitive sensing |
12.3.10. | Parker Hannifin |
12.3.11. | Stretchsense |
12.3.12. | LEAP Technology |
12.3.13. | Technology overview - Piezoelectric sensing |
12.4. | Application examples |
12.4.1. | Applications for skin patch motion sensors |
12.4.2. | Case study - Concussion detection |
12.4.3. | X2 Biosystems |
12.4.4. | US Military head trauma patch / PARC |
12.4.5. | Key conclusions: Motion sensing |
13. | SKIN PATCHES AS A COMMUNICATION GATEWAY TO IMPLANTS |
13.1.1. | Communication with implants |
13.2. | Examples in diabetes management |
13.2.1. | Senseonics |
13.2.2. | Senseonics: The role of the skin patch |
13.3. | Examples in bioelectronic medicine |
13.3.1. | Skin patches with bioelectronic medicine implants |
13.3.2. | NeuroRecovery Technologies |
13.3.3. | Stimwave: Freedom SCS |
13.3.4. | SPR Therapeutics: Sprint PNS |
13.3.5. | Bioness: StimRouter |
13.4. | Other examples |
13.4.1. | Proteus Digital Health |
13.4.2. | GraftWorx |
14. | OTHER APPLICATIONS OF SKIN PATCHES |
14.1. | Pressure ulcer prevention |
14.1.1. | Leaf Healthcare (Smith & Nephew) |
14.2. | Bladder volume sensing (wearable ultrasound) |
14.2.1. | Novioscan |
14.2.2. | Triple W - D Free |
14.3. | Other healthcare & medical applications |
14.3.1. | Acoustic respiration rate (Acurable, Masimo, etc.) |
14.3.2. | UV protection |
14.3.3. | MC10 & L'Oréal: Wisp |
14.3.4. | Lief Therapeutics: Stress Management |
14.4. | Others |
14.4.1. | EOG - eye tracking with skin patches |
15. | MARKET FORECASTS |
15.1.1. | Forecast details and assumptions |
15.2. | Diabetes management forecasts |
15.2.1. | Skin patches and diabetes: Forecast summary |
15.2.2. | Overview: CGM market share and players in 2020 |
15.2.3. | A shifting focus in diabetes management, Historic data: 2010-2020 |
15.2.4. | Historic market data: Glucose test strips |
15.2.5. | Historic market data: CGM |
15.2.6. | Historic market data: Insulin pumps |
15.2.7. | Historic market data: Patch pumps |
15.2.8. | Quantitative forecasts for diabetes and CGM |
15.2.9. | Building a top-down forecast scenario |
15.2.10. | Market data and forecast: Glucose test strips |
15.2.11. | Market data and forecast: CGM (sales volume) |
15.2.12. | Market data and forecast: Insulin pumps (revenue) |
15.2.13. | Market data and forecast: Insulin pumps (sales volume) |
15.2.14. | Full datasets: Skin patches in diabetes management, 2010-2020 (historic) & 2021-2031 (forecast) |
15.2.15. | Full datasets: Diabetes management markets, 2010-2020 (historic) & 2021-2031 (forecast) |
15.3. | Cardiovascular monitoring forecasts |
15.3.1. | Market overview and forecasts |
15.3.2. | Cardiac monitoring skin patches: Historic data: 2010-2020 |
15.3.3. | Cardiac monitoring skin patches: Market forecasts |
15.3.4. | Full dataset with table: 2010-2019 (historic) & 2020-2030 (forecast) |
15.4. | General patient monitoring forecasts |
15.4.1. | Historic market data, 2010-2020 |
15.4.2. | Market forecasts, 2021-2031 |
15.4.3. | Market data and forecasts for wireless inpatient monitoring |
15.4.4. | Market data and forecasts for wireless outpatient monitoring |
15.4.5. | Foetal heart rate monitor forecasts |
15.5. | Electrical stimulation forecasts |
15.5.1. | Electrical stimulation via skin patches: Market data (2010-2019) |
15.5.2. | Electrical stimulation via skin patches: Market forecast (2021-2031) |
15.6. | Temperature sensing forecasts |
15.6.1. | Temperature sensing: Market data and forecasts |
15.7. | Iontophoresis forecasts |
15.7.1. | Iontophoresis via skin patches: Market data (2010-2019) |
15.7.2. | Iontophoresis via skin patches: Market forecast (2020-2030) |
15.8. | Full historic and forecast data tables for all sectors |
15.8.1. | Revenue by skin patch product type (/USD millions) |
15.8.2. | Pricing by skin patch product type (/USD) |
15.8.3. | Revenue by skin patch product type (/USD millions) |
16. | LIST OF 121 ELECTRONIC SKIN PATCH PRODUCTS AND PLAYERS |
16.1. | List of company profiles and interviews |
幻灯片 | 503 |
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预测 | 2031 |
ISBN | 9781913899523 |