1. | EXECUTIVE SUMMARY |
1.1. | Glossary of terms |
1.2. | Colors of biotechnology |
1.3. | What is white biotechnology? |
1.4. | White Biotechnology 2025-2035: scope |
1.5. | Trends and drivers in white biotechnology |
1.6. | Synthetic biology as applied to white biotechnology |
1.7. | Technology trends in white biotechnology |
1.8. | Overview of alternative feedstocks for white biotechnology |
1.9. | Major market challenges for white biotechnology |
1.10. | Technical challenges facing white biotechnology |
1.11. | Products derived from white biotechnology: Overview |
1.12. | Molecules that can be produced through industrial biomanufacturing |
1.13. | Molecules that can be produced through industrial biomanufacturing |
1.14. | Company landscape in white biotechnology |
1.15. | Company landscape in white biotechnology |
1.16. | Next-generation fuels through white biotechnology |
1.17. | Bioplastics through white biotechnology |
1.18. | Navigating biobased polymers from monosaccharides |
1.19. | Common bioplastics and polymer precursors synthesized via white biotechnology |
1.20. | Status of molecules produced through white biotechnology |
1.21. | White biotechnology market share by molecule 2025-2035 |
1.22. | White biotechnology global capacity forecast 2025-2035 |
1.23. | White biotechnology global capacity forecast 2025-2035: Discussion (I) |
1.24. | White biotechnology global capacity forecast 2025-2035: Discussion (II) |
1.25. | Emerging areas of white biotechnology forecast 2025-2035 |
1.26. | IDTechEx circular bioeconomy research |
1.27. | Company profiles |
1.28. | Access More With an IDTechEx Subscription |
2. | INTRODUCTION |
2.1. | Glossary of acronyms |
2.2. | Glossary of acronyms |
2.3. | Glossary of terms |
2.4. | Glossary of terms |
2.5. | Colors of biotechnology |
2.6. | What is white biotechnology? |
2.7. | The bioeconomy and white biotechnology |
2.8. | White Biotechnology 2025-2035: Scope |
3. | MARKET ANALYSIS |
3.1. | Market Drivers for White Biotechnology |
3.1.1. | Market drivers: Demand for biobased products |
3.1.2. | Market drivers: Government regulation on petroleum-based plastic use |
3.1.3. | Market drivers: Regulations that are likely to impact biomanufacturing demand |
3.1.4. | Market drivers: Regulations are driving strong interest in biodegradable plastics in China |
3.1.5. | Market drivers: Government support of biotechnology |
3.1.6. | Market drivers: Government support of biotechnology |
3.1.7. | Market drivers: Carbon taxes |
3.2. | Economic Viability of White Biotechnology |
3.2.1. | Factors affecting the economic viability of white biotechnology projects |
3.2.2. | Effect of the price of Brent crude on biobased products |
3.2.3. | The Green Premium |
3.2.4. | Rising feedstock prices |
3.2.5. | Effect of cell factory on cost |
3.2.6. | Identifying the chemicals with the most potential to become biobased based on price |
3.2.7. | How scale-up affects cost |
3.2.8. | Zymergen: Case study on economics of synthetic biology |
3.2.9. | Case study: LanzaTech |
3.2.10. | Case study: Solazyme |
3.2.11. | Synthetic biology: Shift from commodity products to lower volume, high value markets |
3.2.12. | Major market challenges for white biotechnology |
3.3. | Player, Start-up, and Regional Landscape |
3.3.1. | Production capacity of chemicals from biomanufacturing by region 2025 |
3.3.2. | Regional analysis: Drivers and restraints for biomanufacturing production and demand by region |
3.3.3. | Regional analysis: Location of R&D vs production |
3.3.4. | Regional analysis: Biomanufacturing |
3.3.5. | Regional analysis: Production capacity by region |
3.3.6. | Players: Synthetic biology tools and platforms |
3.3.7. | Players: Vertically integrated biomanufacturing |
3.3.8. | Emerging players segmented by molecule |
3.3.9. | Emerging players segmented by molecule |
3.3.10. | Overview of chemicals and materials companies involved with white biotechnology |
3.3.11. | Overview of chemicals and materials companies involved in white biotechnology |
4. | CELL FACTORIES FOR WHITE BIOTECHNOLOGY |
4.1. | Cell factories for biomanufacturing: Factors to consider |
4.2. | Cell factories for biomanufacturing: A range of organisms |
4.3. | Escherichia coli (E.coli) |
4.4. | Corynebacterium glutamicum (C. glutamicum) |
4.5. | Bacillus subtilis (B. subtilis) |
4.6. | Saccharomyces cerevisiae (S. cerevisiae) |
4.7. | Yarrowia lipolytica (Y. lipolytica) |
4.8. | Microorganisms used in different biomanufacturing processes |
4.9. | Non-model organisms for white biotechnology |
5. | TECHNOLOGY DEVELOPMENTS |
5.1. | Synthetic Biology |
5.1.1. | Synthetic biology: The design and engineering of biological systems |
5.1.2. | Synthetic biology: Manipulating the central dogma |
5.1.3. | The vast scope of synthetic biology |
5.1.4. | The process of synthetic biology: Design, build and test |
5.1.5. | Synthetic biology: Why now? |
5.1.6. | Synthetic biology: From pharmaceuticals to consumer products |
5.1.7. | Synthetic biology: Disrupting existing supply chains |
5.1.8. | Synthetic biology: Drivers and barriers for adoption |
5.1.9. | Synthetic biology as applied to white biotechnology |
5.2. | Tools and Techniques of Synthetic Biology |
5.2.1. | Tools and techniques of synthetic biology: Overview |
5.2.2. | DNA synthesis |
5.2.3. | Introduction to CRISPR-Cas9 |
5.2.4. | CRISPR-Cas9: A bacterial immune system |
5.2.5. | CRISPR-Cas9's importance to synthetic biology |
5.2.6. | Protein/enzyme engineering |
5.2.7. | Computer-aided design |
5.2.8. | Commercial examples of engineered proteins in industrial applications |
5.2.9. | Strain construction and optimization |
5.2.10. | Synergy between synthetic biology and metabolic engineering |
5.2.11. | Framework for developing industrial microbial strains |
5.2.12. | The problem with scale |
5.2.13. | Introduction to cell-free systems |
5.2.14. | Cell-free versus cell-based systems |
5.2.15. | Cell-free systems in the context of white biotechnology |
5.2.16. | Cell-free systems for white biotechnology |
5.2.17. | Commercial implementation of cell-free systems: Solugen |
5.2.18. | Startups pursuing cell-free systems for white biotechnology |
5.2.19. | Startups pursuing cell-free systems for white biotechnology |
5.2.20. | Immobilized enzymes in white biotechnology |
5.2.21. | Immobilized catalysts in white biotechnology |
5.2.22. | Robotics: enabling hands-free and high throughput science |
5.2.23. | Robotic cloud laboratories |
5.2.24. | Automating organism design and closing the loop |
5.2.25. | Artificial intelligence and machine learning |
5.2.26. | Machine learning de novo protein prediction |
5.2.27. | Overview of machine learning based improvements for biomanufacturing |
5.2.28. | AI-driven fermentation platform companies |
5.3. | Improvement of Biomanufacturing Processes |
5.3.1. | Continuous vs batch biomanufacturing |
5.3.2. | Benefits and challenges of continuous biomanufacturing |
5.3.3. | Continuous vs batch biomanufacturing: Key fermentation parameter comparison |
5.3.4. | Machine learning to improve biomanufacturing processes |
5.3.5. | Downstream processing (DSP) improvements |
5.3.6. | Downstream processing (DSP) improvements (2) |
5.3.7. | Perfusion bioreactors |
5.3.8. | Tangential flow filtration (TFF) in downstream bioprocessing |
5.3.9. | Hybrid biotechnological-chemical approaches |
5.3.10. | Process intensification and high-cell-density fermentation |
5.4. | White Biotechnology for Sustainability |
5.4.1. | White biotechnology as a sustainable technology |
5.4.2. | Routes for carbon capture in white biotechnology |
5.4.3. | Autotrophic bacteria for carbon capture through biomanufacturing |
5.5. | Alternative Feedstocks for Biomanufacturing |
5.5.1. | Why use alternative feedstocks for white biotechnology? |
5.5.2. | Food, land, and water competition |
5.5.3. | C1 feedstocks: Metabolic pathways |
5.5.4. | C1 feedstocks: Economic benefits |
5.5.5. | C1 feedstocks: Challenges |
5.5.6. | Non-methane C1 feedstocks |
5.5.7. | C1 feedstocks: Products |
5.5.8. | C1 feedstocks: Gas fermentation |
5.5.9. | C2 feedstocks |
5.5.10. | C2 feedstocks: Products segmented by feedstock |
5.5.11. | C1 and C2 feedstocks: Commercial activity |
5.5.12. | C1 and C2 feedstocks: Commercial activity |
5.5.13. | Lignocellulosic biomass feedstocks |
5.5.14. | Lignocellulosic biomass feedstocks: Challenges |
5.5.15. | Lignocellulosic biomass feedstocks: Challenges |
5.5.16. | Lignocellulosic biomass feedstocks: Products |
5.5.17. | Lignocellulosic biomass feedstocks: Products |
5.5.18. | Lignocellulosic feedstocks: Commercial activity |
6. | BLUE BIOTECHNOLOGY |
6.1. | What is blue biotechnology? |
6.2. | Main biocatalysts of blue biotechnology: Cyanobacteria and algae |
6.3. | Cyanobacteria |
6.4. | Algae |
6.5. | Key drivers and challenges for blue biotechnology |
6.6. | Selected startups in blue biotechnology |
7. | PRODUCTS DERIVED FROM WHITE BIOTECHNOLOGY |
7.1.1. | Products derived from white biotechnology: Overview |
7.2. | Fuels |
7.2.1. | Biofuel generations - conventional & advanced biofuels |
7.2.2. | Biofuel generations |
7.2.3. | Biofuels made from white biotechnology |
7.2.4. | Metabolic pathways to biofuels |
7.2.5. | Bioethanol |
7.2.6. | Next-generation bioethanol |
7.2.7. | Next generation bioethanol: Barriers |
7.2.8. | Next-generation ethanol - operational plants |
7.2.9. | Next-generation ethanol - operational plants |
7.2.10. | Next-generation ethanol - operational plants |
7.2.11. | Next-generation ethanol - operational plants |
7.2.12. | Next-generation ethanol - operational plants |
7.2.13. | Next-generation ethanol - planned plants |
7.2.14. | Next-generation ethanol - planned plants |
7.2.15. | Next-generation ethanol - non-operational and cancelled plants |
7.2.16. | Next-generation ethanol - non-operational and cancelled plants |
7.2.17. | Diesel from biomanufacturing pathways |
7.2.18. | Farnesene |
7.2.19. | n-Butanol |
7.2.20. | Isobutanol |
7.2.21. | Methanol |
7.2.22. | Blue biotechnology in biofuel production |
7.2.23. | Blue biotechnology in biodiesel production |
7.2.24. | Blue biotechnology in bioethanol production |
7.2.25. | Blue biotechnology for biofuel production: Key challenges for commercial viability |
7.2.26. | Blue biotechnology for biofuel production: Commercial activity by US oil producers |
7.2.27. | Blue biotechnology for biofuel production: Commercial activity by non-US oil producers |
7.2.28. | Blue biotechnology for biofuel production: List of current and former players |
7.2.29. | Blue biotechnology for biofuel production: List of current and former players |
7.2.30. | Blue biotechnology for biofuel production: List of current and former players |
7.3. | Plastics and Textiles |
7.3.1. | Introduction to bioplastics |
7.3.2. | Production of bioplastics through white biotechnology |
7.3.3. | Navigating biobased polymers from monosaccharides |
7.3.4. | Common bioplastics and polymer precursors synthesized via white biotechnology |
7.3.5. | Lactic Acid and Polylactic Acid (PLA) |
7.3.6. | Lactic acid (C3H6O3) |
7.3.7. | Lactic acid: Bacterial fermentation or chemical synthesis? |
7.3.8. | Optimal lactic acid bacteria strains for fermentation |
7.3.9. | Engineering yeast strains for lactic acid fermentation |
7.3.10. | Fermentation, recovery and purification |
7.3.11. | What is polylactic acid? |
7.3.12. | Production of PLA |
7.3.13. | PLA production process |
7.3.14. | Polylactic acid: A SWOT analysis |
7.3.15. | Molecules for Other Biobased Synthetic Polyesters |
7.3.16. | The range of available biobased polyesters from bio-manufactured monomers |
7.3.17. | Propylene glycol (PG) or 1,2-propanediol |
7.3.18. | 1,3-Propanediol (1,3-PDO) |
7.3.19. | Biobased PDO and PTT: Monomer production |
7.3.20. | Biobased PDO and PTT: Polymer applications |
7.3.21. | 2,3-Butanediol (2,3-BDO) |
7.3.22. | 1,4-Butanediol (1,4-BDO) |
7.3.23. | Biobased BDO: Monomer production |
7.3.24. | Biobased BDO technology licensed from Geno |
7.3.25. | Biobased BDO and PBT: Polymer applications |
7.3.26. | Succinic acid |
7.3.27. | Biobased succinic acid: Monomer production |
7.3.28. | Biobased succinic acid and PBS: Polymer applications |
7.3.29. | Biobased succinic acid: Project status |
7.3.30. | 2,5-furandicarboxylic acid (FDCA) |
7.3.31. | Biobased FDCA: Monomer production |
7.3.32. | Polyethylene furanoate (PEF) |
7.3.33. | Biobased FDCA and PEF: Polymer applications |
7.3.34. | Molecules for Other Biobased Synthetic Polymers |
7.3.35. | Biosynthetic pathways to polyamides |
7.3.36. | C6: Adipic acid, hexamethylenediamine, and caprolactam |
7.3.37. | C10: Sebacic acid |
7.3.38. | C12: Dodecanedioic acid |
7.3.39. | 1,5-Pentanediamine (PDA) |
7.3.40. | Covestro: PDI and Desmodur eco aliphatic polyisocyanate |
7.3.41. | Cathay Industrial Biotech: TERRYL and ECOPENT biobased polyamides |
7.3.42. | 1,3-Butadiene |
7.3.43. | Status of biomanufacturing-derived butadiene projects |
7.3.44. | Isoprene |
7.3.45. | Isobutene (isobutylene) |
7.3.46. | Naturally Occurring Biobased Polymers: Polyhydroxyalkanoates (PHAs) |
7.3.47. | Introduction to poly(hydroxyalkanoates) |
7.3.48. | Biosynthetic pathways to PHAs |
7.3.49. | Fermentation, recovery and purification |
7.3.50. | Key commercial PHAs and microstructures |
7.3.51. | PHB, PHBV, and P(3HB-co-4HB) |
7.3.52. | Types of PHAs |
7.3.53. | Material properties of commercial PHAs |
7.3.54. | Suppliers of PHAs |
7.3.55. | Short and medium chain-length PHAs |
7.3.56. | PHAs: A SWOT analysis |
7.3.57. | Applications of PHAs |
7.3.58. | Opportunities in PHAs |
7.3.59. | Reducing the cost of PHA production |
7.3.60. | Risks in PHAs |
7.3.61. | PHAs are only made in small quantities |
7.3.62. | PHA production facilities |
7.3.63. | Case Study: Danimer Scientific ends PHA production |
7.3.64. | Conclusions |
7.3.65. | Other Textiles Produced through White Biotechnology |
7.3.66. | Spider silk |
7.3.67. | Collagen-derived textiles |
7.3.68. | Mycelium |
7.4. | Other Chemicals, Precursors, and Additives |
7.4.1. | Acetone |
7.4.2. | Acrylic acid |
7.4.3. | Acetone |
7.4.4. | Itaconic acid |
7.4.5. | Biobased ethanol as a precursor |
7.4.6. | Biomanufacturing of ethylene |
7.4.7. | Monoethylene glycol (MEG) |
7.4.8. | Biobased MEG: Monomer production |
7.4.9. | Biobased MEG: Industry landscape |
7.4.10. | Biobased MEG: Industry landscape |
7.4.11. | Polyethylene terephthalate (PET) |
7.4.12. | Biobased polyolefins |
7.4.13. | Braskem: "I'm green" polyethylene |
7.4.14. | Biomanufacturing of propylene precursors |
7.4.15. | Malonic acid |
7.4.16. | Short chain fatty acids and medium chain fatty acids (SCFAs/MCFAs) |
7.4.17. | Short chain fatty acids and medium chain fatty acids (SCFAs/MCFAs) |
7.4.18. | Short chain fatty acids: Acetic acid |
7.4.19. | Triglycerides |
7.4.20. | Other organic acids and aldehydes |
7.4.21. | Other organic acids and aldehydes |
7.4.22. | Bacterial cellulose |
7.5. | Other Products Derived from White Biotechnology |
7.5.1. | Overview of vitamins and amino acids produced through white biotechnology |
7.5.2. | Overview of white biotechnology for cosmetics |
7.5.3. | Biomanufacturing for surfactants and detergents |
7.5.4. | Enzymes for onward use: Novozymes |
7.5.5. | Cement alternatives from biomanufacturing: BioMason |
7.5.6. | Precision fermentation: Definition and scope |
8. | FORECASTS FOR WHITE BIOTECHNOLOGY |
8.1. | Forecast methodology |
8.2. | White biotechnology market share by molecule 2025-2035 |
8.3. | White biotechnology global capacity forecast 2025-2035 |
8.4. | White biotechnology global capacity forecast 2025-2035: Discussion (I) |
8.5. | White biotechnology global capacity forecast 2025-2035: Discussion |
8.6. | White biotechnology global capacity forecast 2025-2035: Discussion |
8.7. | Emerging areas of white biotechnology forecast 2025-2035 |
8.8. | Emerging areas of white biotechnology forecast: Discussion |
9. | COMPANY PROFILES |
9.1. | Afyren |
9.2. | Arzeda |
9.3. | Biomason |
9.4. | Bolt Threads |
9.5. | Braskem |
9.6. | Cathay Biotech |
9.7. | CarbonBridge |
9.8. | Celtic Renewables |
9.9. | Chaincraft |
9.10. | CyanoCapture |
9.11. | Ecovative |
9.12. | Enginzyme |
9.13. | Enzymaster |
9.14. | Industrial Microbes |
9.15. | Kraig Biocraft Laboratories |
9.16. | LanzaTech (2023) Update |
9.17. | LanzaTech |
9.18. | Mango Materials |
9.19. | Modern Meadow |
9.20. | New Energy Blue |
9.21. | Novozymes |
9.22. | Q Power |
9.23. | Spiber |
9.24. | Henan Techuang Biotechnology |
9.25. | Huitong Biomaterials |
9.26. | Total Energies Corbion |
9.27. | Teijin Frontier: PLA |
9.28. | Natureworks |
9.29. | Biotic Circular Technologies |
9.30. | Bluepha |
9.31. | CJ Biomaterials |
9.32. | Danimer Scientific (2024 Update - Now bankrupt) |
9.33. | Danimer Scientific |
9.34. | Fortum: INGA Plastic |
9.35. | Kaneka |
9.36. | Newlight Technologies (Not currently operational) |
9.37. | Ourobio |
9.38. | Paques Biomaterials |
10. | APPENDIX |
10.1. | White biotechnology global capacity forecast 2025-2035 |
10.2. | Emerging areas of white biotechnology forecast 2025-2035 |